The Stillbirth Collaborative Research Network Postmortem Examination Protocol

Halit Pinar; Matthew A. Koch; Hal Hawkins; Josefine Heim-Hall; Carlos R. Abramowsky; Vanessa R. Thorsten; Marshall W. Carpenter; Hong Holly Zhou; Uma M. Reddy

doi:10.1055/s-0031-1284228

American Journal of Perinatology, Table of Contents

Am J Perinatol 2012; 29(03): 187-202
DOI: 10.1055/s-0031-1284228

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Stillbirth Collaborative Research Network Postmortem Examination Protocol

Halit Pinar

¹Division of Perinatal Pathology, Women and Infants Hospital, Brown University, Alpert School of Medicine, Providence, Rhode Island

,

Matthew A. Koch

²Department of Statistics and Epidemiology, RTI International Research Triangle Park, Research Triangle Park, North Carolina

,

Hal Hawkins

³Department of Pediatric Pathology, UTMB at Galveston, Galveston, Texas

,

Josefine Heim-Hall

⁴Josefine Heim-Hall, UTHSC at San Antonio School of Medicine, San Antonio, Texas

,

Carlos R. Abramowsky

⁵Pathology Laboratory, Egleston Hospital, Atlanta, Georgia

,

Vanessa R. Thorsten

⁶Department of Statistics and Data Analysis, RTI International, Kansas City, Missouri

,

Marshall W. Carpenter

⁷Department of Maternal and Fetal Medicine, Tufts University School of Medicine, Boston, Massachusetts

,

Hong Holly Zhou

⁸Department of Pediatric Pathology, Primary Children's Medical Center, Salt Lake City, Utah

,

Uma M. Reddy

⁹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

› Author Affiliations

Abstract

After reviewing the state of knowledge about the scope and causes of stillbirth (SB) in a special workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the participants determined that there is little guidance regarding the best use of postmortem examination (PM) to address the pathogenesis of stillbirth. In this report, we describe the PM procedure designed and used in the NICHD-supported Stillbirth Cooperative Research Network (SCRN). Perinatal pathologists, clinicians, epidemiologists, and biostatisticians at four tertiary care centers, a data coordinating center, and NICHD developed a standardized approach to perinatal PM, which was applied to a population-based study of stillbirth as part of the SCRN. The SCRN PM protocol was successfully instituted and used at the four medical centers. A total of 663 women with stillbirth were included: 620 delivered a single stillborn infant, 42 delivered twins, and one delivered triplets for a total of 676 stillborn infants. Of these women, 560 (84.5%) consented to PM (572 stillborn infants) that was conducted according to the SCRN protocol. A standardized PM protocol was developed to evaluate stillbirth consistently across centers in the United States. Novel testing and approaches that increase the yield of the PM can be developed using this model.

Keywords

SCRN - postmortem examination - stillbirth - perinatal pathology

Full Text

References

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